Back to Trasylol®

Anaphylactic or anaphylactoid reactions are possible when Trasylol® is used during coronary artery bypass graft surgery or any other heart surgery. Hypersensitivity reactions are rare in patients with no prior exposure to Trasylol®. Hypersensitivity can range from:

• Skin Eruptions
• Sweating
• Itching
• Dyspnea
• Nausea
• Tachycardia
• Circulatory Failure
• Anaphylactic Shock
• Death

Adverse Reactions

Early studies undergoing CABG surgery indicated that Trasylol® was generally well tolerated. The adverse events reported are frequent sequelae of cardiac surgery and are not necessarily attributable to Trasylol® therapy. Adverse events reported from patients in U.S. placebo-controlled trials are listed in the following table. The table lists only those events that were reported in 2% or more of the Trasylol® treated patients without regard to causal relationship.

Adverse Event

Body as a Whole

• Fever
• Chest Pain Asthenia
• Infection
• Asthenia

Cardiovascular

• Atrial Fibrillation
• Hypotension
• Atrial Flutter
• Mydicardial Infarct
• Ventricular Extrasystoles
• Tachycardia
• Ventricular Tachycardia
• Pericarditis
• Heart Failure
• Peripheral Edema
• Hypertension
• Arrhythmia
• Supraventricular Tachycardia
• Atrial Arrhythmia

Digestive

• Nausea
• Vomiting
• Diarrhea
• Constipation
• Liver Function Tests Abnormal

Metabolic and Nutritional

• Creatine Phosphokinase Increased

Hemic and Lymphatic

• Anemia

Nervous

• Confusion
• Insomnia

Respiratory

• Pleural Effusion
• Dyspnea
• Lung Disorder
• Pleural Effusion
• Atelectasis
• Asthma
• Hypoxia
• Pneumothorax

Skin and Appendages

• Rash

Urogenital

• Kidney Function Abnormal
• Urinary Tract Infection
• Urinary Retention

Additional Events

• Thrombosis
• Shock
• Cerebrovascular Accidents
• Deep Thrombophlebitis
• Thrombophlebitis
• Kidney Failure
• Lung Edema
• Pulmonary Embolus
• Kidney Tubular Necrosis
• Acute Kidney Failure

If you or someone you know has undergone a coronary artery bypass grafting surgery and subsequently developed the onset of kidney failure, please use the form on the left to contact our law firm.

Reference:

"Trasylol® (aprotinin injection)," Bayer, December 2003.